Pomegranate extract mechanism in inhibiting the development of oral cancer: A review

Background: Oral cancer is one of the most aggressive and invasive cancers with high metastatic potential. 11th highest number cases in world. treated chemotherapy radiotherapy. However, this therapy causes side effects form damage to normal cells surrounding tissue. Pomegranate extract contains polyphenols which may be great for inhibiting development oral cancer. Purpose: This article presents a systematic comprehensive review potential pomegranate as natural product inhibit Review: was obtained by ethanol extraction using maceration method. The main content polyphenolic compounds such punicalagin, tannins, flavonoids, ellagic acid. compound reduces ATP formation, shortens subG1 phase, increases apoptosis. At microcellular level, can activity MMP-2 or MMP-9 produce anti-proliferative, anti-angiogenesis pro-apoptotic processes at concentrations 25 50 μg/ml. Anti-proliferative are produced through mitochondrial mechanisms. Exposure after 72 hours reduce cell viability greater than exposure 24 hours. Conclusion: likely has four mechanisms cancer: invasion, migration growth cells, increasing apoptosis regulating antioxidant genes. So that material used candidate therapy.